Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2011 1
2012 3
2013 1
2014 1
2017 1
2019 1
2020 2
2022 1
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

11 results

Results by year

Filters applied: . Clear all
Page 1
Landscape of transcriptome variations uncovering known and novel driver events in colorectal carcinoma.
Pira G, Uva P, Scanu AM, Rocca PC, Murgia L, Uleri E, Piu C, Porcu A, Carru C, Manca A, Persico I, Muroni MR, Sanges F, Serra C, Dolei A, Angius A, De Miglio MR. Pira G, et al. Sci Rep. 2020 Jan 16;10(1):432. doi: 10.1038/s41598-019-57311-z. Sci Rep. 2020. PMID: 31949199 Free PMC article.
Among the genes showing alternative splicing, cell cycle related genes were upregulated (CCND1, CDC25B, MCM2, MCM3), while genes involved in fatty acid metabolism (ACAAA2, ACADS, ACAT1, ACOX, CPT1A, HMGCS2) were downregulated. Overall 148 genes showed differential s …
Among the genes showing alternative splicing, cell cycle related genes were upregulated (CCND1, CDC25B, MCM2, MCM3), while genes involved in …
Intestinal Lipid Metabolism Genes Regulated by miRNAs.
Ruiz-Roso MB, Gil-Zamorano J, López de Las Hazas MC, Tomé-Carneiro J, Crespo MC, Latasa MJ, Briand O, Sánchez-López D, Ortiz AI, Visioli F, Martínez JA, Dávalos A. Ruiz-Roso MB, et al. Front Genet. 2020 Jul 10;11:707. doi: 10.3389/fgene.2020.00707. eCollection 2020. Front Genet. 2020. PMID: 32742270 Free PMC article.
The levels of 83 cholesterol and lipoprotein metabolism-related genes were assessed in the intestinal mucosa of Int-Dicer1 KO and Wild Type C57BL/6 (WT) littermates mice at baseline and 2 h after an oral lipid challenge. Among the 18 genes selected for further validation, Hmgc …
The levels of 83 cholesterol and lipoprotein metabolism-related genes were assessed in the intestinal mucosa of Int-Dicer1 KO and Wild Type …
Transcriptome Analysis of Bovine Rumen Tissue in Three Developmental Stages.
Zhang Y, Cai W, Li Q, Wang Y, Wang Z, Zhang Q, Xu L, Xu L, Hu X, Zhu B, Gao X, Chen Y, Gao H, Li J, Zhang L. Zhang Y, et al. Front Genet. 2022 Mar 3;13:821406. doi: 10.3389/fgene.2022.821406. eCollection 2022. Front Genet. 2022. PMID: 35309117 Free PMC article.
Functional annotation and protein-protein interaction (PPI) network analysis revealed that CCNB1, CCNB2, IGF1, IGF2, HMGCL, BDH1, ACAT1, HMGCS2, and CREBBP involved in rumen development. Integrated transcriptome with GWAS information of carcass weight (CW), stomach …
Functional annotation and protein-protein interaction (PPI) network analysis revealed that CCNB1, CCNB2, IGF1, IGF2, HMGCL, BDH1, ACAT1 …
Jersey steer ruminal papillae histology and nutrigenomics with diet changes.
Novak TE, Rodriguez-Zas SL, Southey BR, Starkey JD, Stockler RM, Alfaro GF, Moisá SJ. Novak TE, et al. J Anim Physiol Anim Nutr (Berl). 2019 Nov;103(6):1694-1707. doi: 10.1111/jpn.13189. Epub 2019 Sep 4. J Anim Physiol Anim Nutr (Berl). 2019. PMID: 31483547 Free PMC article.
Genes related to cell membrane structure (CLDN1, CLDN4, DSG1), fatty acid metabolism (CPT1A, ACADSB), glycolysis (PFKL), ketogenesis (HMGCL, HMGCS2, ACAT1), lactate/pyruvate (LDHA), oxidative stress (NQO1), tissue growth (AKT3, EGFR, EREG, IGFBP5, IRS1) and the urea …
Genes related to cell membrane structure (CLDN1, CLDN4, DSG1), fatty acid metabolism (CPT1A, ACADSB), glycolysis (PFKL), ketogenesis (HMGCL, …
Ketone body utilization drives tumor growth and metastasis.
Martinez-Outschoorn UE, Lin Z, Whitaker-Menezes D, Howell A, Sotgia F, Lisanti MP. Martinez-Outschoorn UE, et al. Cell Cycle. 2012 Nov 1;11(21):3964-71. doi: 10.4161/cc.22137. Epub 2012 Sep 19. Cell Cycle. 2012. PMID: 23082722 Free PMC article.
For this purpose, we generated hTERT-immortalized fibroblasts overexpressing the rate-limiting enzymes that promote ketone body production, namely BDH1 and HMGCS2. Similarly, we generated MDA-MB-231 human breast cancer cells overexpressing the key enzyme(s) that allow keto …
For this purpose, we generated hTERT-immortalized fibroblasts overexpressing the rate-limiting enzymes that promote ketone body production, …
Extracting time-dependent obese-diabetic specific networks in hepatic proteome analysis.
Midha MK, Tikoo K, Sinha N, Kaur S, Verma HN, Rao KV, Chatterjee S, Manivel V. Midha MK, et al. J Proteome Res. 2012 Dec 7;11(12):6030-43. doi: 10.1021/pr300711a. Epub 2012 Nov 8. J Proteome Res. 2012. PMID: 23050596
The functionally important modules with key hub proteins such as Egfr, Pklr, Suclg1, and Pcx (Carbohydrate metabolism), Cyp2e1, Fasn, Acat1, and Hmgcs2 (Lipid metabolism and ketogenesis), and Gpx1, Mgst1, and Sod2 (ROS metabolism) can be linked to a physiological st …
The functionally important modules with key hub proteins such as Egfr, Pklr, Suclg1, and Pcx (Carbohydrate metabolism), Cyp2e1, Fasn, Aca …
Icariin is a PPARα activator inducing lipid metabolic gene expression in mice.
Lu YF, Xu YY, Jin F, Wu Q, Shi JS, Liu J. Lu YF, et al. Molecules. 2014 Nov 6;19(11):18179-91. doi: 10.3390/molecules191118179. Molecules. 2014. PMID: 25383754 Free PMC article.
The mRNAs of mitochondrial FA beta-oxidation enzymes (Cpt1a, Acat1, Acad1 and Hmgcs2) were increased 2-3 fold. The mRNAs of proximal beta-oxidation enzymes (Acox1, Ech1, and Ehhadh) were also increased by icariin and clofibrate. ...
The mRNAs of mitochondrial FA beta-oxidation enzymes (Cpt1a, Acat1, Acad1 and Hmgcs2) were increased 2-3 fold. The mRNAs of pr …
Grain challenge affects systemic and hepatic molecular biomarkers of inflammation, stress, and metabolic responses to a greater extent in Holstein than Jersey cows.
Xu T, Cardoso FC, Pineda A, Trevisi E, Shen X, Rosa F, Osorio JS, Loor JJ. Xu T, et al. J Dairy Sci. 2017 Nov;100(11):9153-9162. doi: 10.3168/jds.2017-13321. Epub 2017 Aug 31. J Dairy Sci. 2017. PMID: 28865848 Free article. Clinical Trial.
In Holsteins fed HIG versus CON, the marked downregulation of SCD, ELOVL6, and MTTP along with upregulated CPT1A, ACOX1, and APOA5 indicated alterations in fatty acid and lipoprotein metabolism during grain challenge. Genes related to ketogenesis (HMGCS2 and ACAT1) …
In Holsteins fed HIG versus CON, the marked downregulation of SCD, ELOVL6, and MTTP along with upregulated CPT1A, ACOX1, and APOA5 indicated …
Ketone bodies and two-compartment tumor metabolism: stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells.
Martinez-Outschoorn UE, Lin Z, Whitaker-Menezes D, Howell A, Lisanti MP, Sotgia F. Martinez-Outschoorn UE, et al. Cell Cycle. 2012 Nov 1;11(21):3956-63. doi: 10.4161/cc.22136. Epub 2012 Sep 19. Cell Cycle. 2012. PMID: 23082721 Free PMC article.
Finally, using human breast cancer tumor samples, we directly confirmed that the enzymes associated with ketone body production (HMGCS2, HMGCL and BDH1) were preferentially expressed in the tumor stroma. Conversely, enzymes associated with ketone re-utilization (ACAT1 …
Finally, using human breast cancer tumor samples, we directly confirmed that the enzymes associated with ketone body production (HMGCS2 …
Quantitative proteomics reveals that enzymes of the ketogenic pathway are associated with prostate cancer progression.
Saraon P, Cretu D, Musrap N, Karagiannis GS, Batruch I, Drabovich AP, van der Kwast T, Mizokami A, Morrissey C, Jarvi K, Diamandis EP. Saraon P, et al. Mol Cell Proteomics. 2013 Jun;12(6):1589-601. doi: 10.1074/mcp.M112.023887. Epub 2013 Feb 26. Mol Cell Proteomics. 2013. PMID: 23443136 Free PMC article.
After analyzing the remaining enzymes of this pathway (ACAT1, BDH1, HMGCL, and OXCT1), we observed increased expression of these proteins in the LNCaP-SF cells, which was further verified using Western blotting. ...In addition, we observed significant elevation of these en …
After analyzing the remaining enzymes of this pathway (ACAT1, BDH1, HMGCL, and OXCT1), we observed increased expression of these prot …
11 results